Isogeometric Analysis of Cardiac Electrophysiology: Application to the Human Atria
نویسنده
چکیده
Acknowledgements I would like to express my gratitude to Professor Alfio Quarteroni, who gave me the possibility to work within the Chair of Modeling and Scientific Computing (CMCS) to my Master Project, and to Luca Dedè, who was very supportive during these months and always available to provide valuable advice and ideas. My thanks go to everyone in the CMCS group, in particular to Andrea and Filippo, with whom I shared the office and most of the moments of my last semester as a student. I would like to thank my friends in Lausanne, especially Edoardo, Francesco, Giacomo, Nicolo' and Philippe, who helped me during the past two years to make me feel at home even when home was 360 km away, and my friends in Italy, Mauro and Veronica, who make me feel as I had never left. I would like to thank my family – my parents, my brother and my sister – who have always supported my choices. I dedicate to them this work. Lastly, I would like to thank Virginia, for always being caring and encouraging.
منابع مشابه
NURBS-Based Isogeometric Analysis Method Application to Mixed-Mode Computational Fracture Mechanics
An interaction integral method for evaluating mixed-mode stress intensity factors (SIFs) for two dimensional crack problems using NURBS-based isogeometric analysis method is investigated. The interaction integral method is based on the path independent J-integral. By introducing a known auxiliary field solution, the mixed-mode SIFs are calculated simultaneously. Among features of B-spline basis...
متن کاملEffect of Sodium Valproate on Ouabain-Induced Arrhythmia in Isolated Guinea-Pig Atria
Sodium valproate (SV), an antiepileptic drug has several mechanism of action. It inhibits voltage sensitive Na+ channels and reduces intracellular Na accumulation. These actions are similar to that of both phenytoin and carbamazepine. We have investigated the direct cardiac action of SV and its effects on ouabain-induced arrhythmia in isolated guinea-pig atria. The guinea-pig atrium was dissect...
متن کاملA membrane model of electrically remodelled atrial myocardium derived from in vivo measurements.
AIMS Contemporary ionic-based membrane models are computationally expensive and are not intended to match the properties of a given experimental preparation. The aim of this work was to use measured restitution properties of electrically remodelled atrial tissue to develop a simplified membrane model based on the Fenton-Karma (FK) equations amenable to large-scale simulation of chronic atrial f...
متن کاملNovel frameshift mutation in the KCNQ1 gene responsible for Jervell and Lange-Nielsen syndrome
Objective(s): Jervell and Lange–Nielsen syndrome is an autosomal recessive disorder caused by mutations in KCNQ1 or KCNE1 genes. The disease is characterized by sensorineural hearing loss and long QT syndrome. Methods: Here we present a 3.5-year-old female patient, an offspring of consanguineous marriage, who had a history of recurrent syncope and congenital sensorineural deafness. The patient ...
متن کاملIMPOSITION OF ESSENTIAL BOUNDARY CONDITIONS IN ISOGEOMETRIC ANALYSIS USING THE LAGRANGE MULTIPLIER METHOD
NURBS-based isogeometric analysis (IGA) has currently been applied as a new numerical method in a considerable range of engineering problems. Due to non-interpolatory characteristic of NURBS basis functions, the properties of Kronecker Delta are not satisfied in IGA, and as a consequence, the imposition of essential boundary condition needs special treatment. The main contribution of this study...
متن کامل